Selected Publications

FDX1 regulates cellular protein lipoylation through direct binding of LIAS.
Dreishpoon M, Bick RN, Petrova B, Warui MW, Camron A, Booker JS, Kanarek N, Santagata S, Golub TR, Tsvetkov P*.
J Biol Chem, 2023 September. Volume 299, Issue 9.

Copper induces cell death by targeting lipoylated TCA cycle proteins.
Tsvetkov P* , Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton J, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR*.
Science, 2022 Mar 18;375(6586):1254-1261.

Highlighted in:
Cellular & Molecular Immunology
Cell Research
Molecular Cell
Science

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, Tang Y, Lam HC, Tsvetkov P, Georgiou G, Lamb C, Stone E, Puigserver P, Priolo C, Henske EP.
Proc Natl Acad Sci U S A, 2022 Jul 12;119(28):e2122840119.

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Tsvetkov P*, Eisen TJ, Heinrich S, Brune Z, Newby GA, Hallacli E, Kayatekin C, Pincus D, Lindquist S
Cell Reports 2020 Aug 11;32(6):108001. * Corresponding

Mitochondrial metabolism promotes adaptation to proteotoxic stress.
Tsvetkov P *, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR *.
Nat chem biol. 2019 Jul;15(7):681-689. *Co-corresponding

Oncogenic addiction to high 26S proteasome level.
Tsvetkov P*, Adler J*, Myers N, Biran A, Reuven N, Shaul Y.
Cell Death Dis. 2018 Jul 10;9(7):773. * Equal contribution

A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.
Newby GA, Kiriakov S, Hallacli E, Kayatekin C, Tsvetkov P, Mancuso CP, Bonner JM, Hesse WR, Chakrabortee S, Manogaran AL, Liebman SW, Lindquist S, Khalil AS.
Cell. 2017 Nov 2;171(4):966-979.e18.

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.
Tsvetkov P*, Sokol ES, Jin D, Brune Z, Thiru P, Ghandi M, Garraway LA, Gupta PB, Santagata S, Whitesell L, Lindquist S.
Proc Natl Acad Sci. 2017 Jan 10;114(2):382-387. *  Corresponding author

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.
Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S.
Elife.2015 Sep 1:4:e08467.

NADH binds and stabilizes the 26S proteasomes independent of ATP.
Tsvetkov P *, Myers N, Eliav R, Adamovich Y, Hagai T, Adler J, Navon A, Shaul Y *.
J Biol Chem.2014 Apr 18;289(16):11272-81.* Co-corresponding authors

BIMEL, an Intrinsically Unstructured Protein, is Degraded by the 20S Proteasome in the Absence of Poly-Ubiquitination
Wiggins,C., P. Tsvetkov,  M.Johnson, C.Joyce, C.Lamb, N.Bryant, D.Komander, Y.Shaul and S.Cook,.
 J Cell Sci 124, 969-977. 2011

The E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer patients
Tsvetkov, P.,Y. Adamovich, E. Elliott and Y. Shaul.
J Biol Chem, 2011 Mar 18;286(11):8839-45.

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response*.
Tsvetkov, P., N. Reuven, C. Prives, and Y. Shaul.
J Biol Chem, 2009. 284(39): p. 26234-42. * Selected paper of the week.